Patient Education Plan Essay

This is a Patient Education Plan for a patient suffering from a gastrointestinal disease called liver cirrhosis. Gastrointestinal infection is said to be any communicable disease which involves the gastrointestinal tract making it as its portal of entry of affecting it by any means. The organisms which produce toxins cause this kind of infectious intestinal disease all by themselves. Thus, cirrhosis is an irreversible type of liver damage described as a dense scarring (fibrosis) of the hepatic tissues. In the United States, the major causes are excessive alcohol consumption and viral Hepatitis C. Other known causes include chronic hepatitis B and D, iron overload, autoimmune/inherited diseases, chronic bile duct obstruction, and drugs, toxins and other infections as well. The patient in this specific case is a 38-year old male who has been working as a gardener and janitor in one of the prestigious learning institutions in the United States. Even if he is only 38, he looks like he is 50 years old already. Let us call him â€Å"Dave† for purposes of confidentiality and patient protection. Dave is the breadwinner of a family of five. He has three children and his wife is working as a clerk for an agency within the neighborhood. Being a gardener and a janitor at the same time, he is often on duty the whole day under the intense heat of the sun with little rest or no rest at all. He also works daily without any rest days and frequently engages in over time to get extra pay to sustain life’s needs. Patient 2 Because of too much toiling done, Dave believes he deserves to relax after work so he always drinks alcohol to relax his muscles. This has become a regular habit of his for the past 15 years. It all began as a relaxing strategy until it has become a daily habit. Drinking has become his idea of socialization. Though he knows the dilemmas of habitual drinking, he is finding a hard time to get himself to minimize or stop drinking. Even at work, he keeps a bottle secretly kept so he can take sips or gulps from time to time while keeping himself busy. It has become as sort-of water to him. It should be noted that before Dave became an alcoholic, he has a large frame weighing 180 lbs. and standing at 5 feet and 11 inches. After he became an alcoholic, he now weighs only 150 lbs. which is way below his ideal weight. His skin wrinkled and darkened but with tinges of yellowish areas all throughout his body. His body bulged since his liver has inflamed already and edema has occurred inside him. Physically, one will know right then that he is sick. As to his family history, it is important to be aware that his father was also a habitual drinker but lucky enough for him that he did not develop liver cirrhosis. However, two brothers of his father had liver cirrhosis and one of them died of the disease. Therefore, said gastrointestinal disease runs in their family. Dave had a chance of going to college but because of attitude problems he fell short and finished only high school. So he ended up with a menial job as a school gardener and janitor. Based on his scholastic records, he was a good student. He gained good grades, not academically rewarding but decent enough to pass college scholarships. His alleged stubborn traits had won him over. Patient 3 The patient, Dave, preferred to engage in one-to-one learning technique rather than learning by group method. Dave has several sensitive, private and critical issues which he opts to share only with the learning provider, in this case, the nurse. In fact, Dave did not even approved of the idea of â€Å"learning† at first because of his stubbornness. He wants to do things alone but with thorough explanation, he was able to understand his condition little by little and began cooperating to work on his sick state. So what is liver cirrhosis all about? The disease has been defined earlier as a form of liver damage which affects the gastrointestinal system. Among the early signs include weakness/fatigue, anorexia, stomatitis, tea-colored urine, clay-colored stool, amenorrhea, decreased sexual urge, loss of pubic and axilla hair, hepatomegaly, jaundice, and pruritus or urticaria. Late signs involve hematological, endocrine, GIT and neurological changes. Further, it can complicate into more serious illnesses such as edema and ascites (fluid buildup), bruising and bleeding, jaundice, itching, gallstones, toxins in the blood or brain leading to impaired brain function, kidney failure, sensitivity to medication, portal hypertension, varices, insulin resistance and Type 2 diabetes, liver cancer and problems with other organs. In Dave’s case, it began as a severe case of alcoholism combined with malnutrition which led Laennec’s cirrhosis. This went on to the destruction of hepatic cells or hepatocytes then fibrosis or scarring. Following thereafter is an obstruction of blood flow which increases pressure in the venous and sinusoidal channels then fatty infiltration leading to further fibrosis or scarring. Finally, portal hypertension or high blood pressure (hypertension) in the portal veins and its branches resulted. Patient 4 The prevalence of liver cirrhosis can come across all ages starting at the age of 21 but as the age increases, the rate of scarring progression increases as well. This means that liver cirrhosis cases are more serious with higher age. In Dave’s case, his age may directly affect the severity of his condition. Development of his illness was hastened in that it has been at least 15 years since he became a habitual drinker. It was accumulated through time and in his case, progression is faster compared to others. Because of his liver disease, he cannot work as a gardener and janitor anymore as these are jobs which require much strength and energy. He cannot fulfill his responsibilities at home and his family as well since his health is generally impaired. Further, he cannot participate in community activities too. Patient needs to be educated regarding his nutritional needs. He must monitor his calorie intake and the amounts and kinds of food that he takes to avoid obesity. If possible, he must be given a schedule of diet so he can eat the right kinds of food at the right time and place. Moreover, he must be taught how to improve his depreciating self-esteem due to inability to fulfill his usual duties. He must develop healthy lifestyle practices and new behaviors which will help him regain his confidence. From this moment on, Dave must be able to recover from his health and personality deficiencies. Instead of feeling down and troubled, he must mature by seeing the brighter side of life. The key is acceptance of his present condition and avoid feeling regretful and confused as much as possible. This can be done more competently with the support of the nurse and the significant others who are connected to him.

Mauritius, Social Housing: Social Movement and Low Income Housing in Mauritius Essay

Social Housing Social Movement and Low Income Housing in Mauritius Abstract: The Republic of Mauritius has been a model success story in both economic and social progress among both the African nations and the whole world. Despite many odds, the country has made tremendous economic progress and has succeeded at the same time to uplift significantly the living standards of the population in general. This paper gives an overview of the matter of the low-income housing in Mauritius. The first part of the paper gives the economical background and the evolution of the social movement in Mauritius. The second part introduces the current housing conditions and the situation of poverty and low-income groups in Mauritius. Finally the strategy of social housing is discussed. The Mauritius social housing strategy is discussed in terms of the changes in the institutional structure, and policies. Then the types of social housing and their financing are introduced. Keywords: Mauritius; Welfare State; Social Housing; Low Income Households AUTAR Bhotish Awtar | | Matric No: 2011280122 | Masters Candidate Tsinghua University | School of Architecture | Department of Urban Planning Please submit any feedback to bhotish@hotmail. om Submitted to: |dengweizyh@mail. tsinghua. edu. cn | Submission date: 17th June 2012 Introduction At independence, Mauritius did not appear predestined for the progress that followed. Challenges included: extreme cultural diversity as well as racial inequality; power concentrated in a small elite (of French & British colonial descendants); high unemployment; and high population growth. The country suffered from an economic crisis throughout the 1970s, was remote from world markets and was commodity dependent. It also exhibited low initial levels of human development. Nobel Laureate for Economics, James Meade even said in 1961, as quoted below: â€Å"It is going to be a great achievement if Mauritius can find productive employment for its population without a serious reduction in the existing standard of living†¦ The outlook for peaceful development is poor† Despite multiple factors stacked against it, Mauritius has achieved stellar progress in economic conditions, and has been unique in its ability to take advantage of privileged access to international markets to develop in a sustained and equitable manner. This has been enabled and complemented by effective poverty reduction and equitable improvements in human development. These achievements have been made by means of: a concerted strategy of nation building; strong and inclusive institutions; high levels of equitable public investment in human development; and a pragmatic development strategy (Vandemoortele, 2010). This success against all odds was coined as the ‘Mauritian Miracle’. In independence year of 1968, the country’s GDP per capita was US$ 2601, and in 2010, the figure rose to around US$ 14,0002 in 2010. Comparatively, in 2010 the average GNI per capita (PPP) for Sub-Saharan Africa stood at 2,1083. During the same period of 1968 to 2010, population rose from 787,000 to 1,281,0004. In 2011, an expectancy of life of 73 years5 at birth and the country had a Human Development Index (HDI) score of 7. 26, compared with an average of 4. 6 in the Sub-Saharan African region. The country was also ranked highest on the Earth Institute’s World Happiness Index among the Sub-Saharan African countries7, leaving behind Botswana and South Africa, other regional economic champions. Socialist movement in Mauritius Mauritius is a welfare state. It has a comprehensive social security system for the whole population and various other social protection schemes. Education is free from primary to university level, with 1 2 Source: IFAD, 2005 For 2010, GDP per capita (PPP) of US$ 14,194, according to IMF, 2011 World Economic Outlook, and GNI per capital (PPP) of 13,960 (units International Dollar) according to World Bank, 2011 3 (units International Dollar) according to World Bank, 2011 4 Figures for population for Republic of Mauritius is from various open source, such as Mauritius CSO, World Bank and other online open data sources. Source: UN Statistics, from WorldBank. org 6 Source: http://hdr. undp. org 7 Mauritius Ranking 64th out of 156 countries with 5. 5 points, on a 0-10 scale, 0 being extremely unhappy and 10 being extremely happy compulsory education up to age of 16. Health care including tertiary care, like heart surgery) is also free. Basic foodstuffs (rice and flour) as well as housing for lower middle-income group are heavily subsidized. Income support is provided to household with low income. The government provides nnual grants to a number of NGOs that cater for the specific needs of handicapped persons and vulnerable groups (Deerpalsingh, 2011). There are also price controls on some other commodities such as cement, petroleum products, bread, onions and edible oils. The state plays a key role in social welfare and security. In fact, expenditure on community and social services attracts the largest share of total government expenditure. The percentage out of total government expenditure spent on health, education, social security and welfare, and housing, over the period 1980 to 1988 averaged 43% and by 1999 was as high as 52%. Preferential access to markets in the European Union and the USA has facilitated this strong welfare state (Bundoo, 2006) The construction of a comprehensive welfare state in Mauritius did not emerge out of a smooth and steady process. Each of the three episodes of welfare reform – the formal introduction of noncontributory old-age pensions in 1950, family allowances in 1962 and social insurance in 1976-1978, were borne out of long-periods of deliberation and procrastination from the colonial officials (Phaahla, 2000). It took riots by unorganized sugar estate workers in the late 1930’s and strong trade unions today, to obtain and maintain a particularly socialist environment in the country, despite, a very open and capitalist market economy in Mauritius, it has been succeeded to preserve a considerable labor protection and benefit to the workers. In the more modern times, the social movement is directly related to the democratic governmental system. Around every five years general elections are held, and the public’s voting of a certain party is very sensitive to the economic and social conditions of the country. In many instances in the history, after independence, the government has been ‘overthrown’ out of office, as sanction voting by the population, due to bad economic and social performances. The most popular example, would perhaps in the 1982, elections when the government in office, with the ‘father of the nation’ as the head of the country, faced the worse possible defeat. This was because the unemployment and other economic and social indicators were all in the red. In terms of social services, Mauritius has been practicing a s ‘five pillar’ model as advocated by the World Bank in a report in 2005. But, it is worth noting that the five-pillar system in Mauritius was completed as far back as 1994. So, Mauritius had already been implementing the social model for 11 years (Deerpalsingh, 2011). Providing decent shelter for low-income groups has been another major social priority of the government. In the face of the rising price of rented accommodation, the government initiated projects for the construction of working-class flats in different parts of the country. The National Housing Development Corporation (NHDC) was set up in order to expedite large-scale construction of low-cost housing. House ownership grew from 66 per cent in 1983 to almost 93 per cent in 20018. Current Housing Conditions To understand the access to housing to the low income household, it is important to understand the general housing condition of the Mauritian. This helps in explaining the ownership policies and housing types that are provided to those who have financial difficulty in possessing a shelter comparable to his fellow countryman. With around $ 14,000 per capita GDP (PPP), Mauritius currently has a relatively high housing quality. In the 2011 Housing survey, it was noted that around 89% of the building stock in the country were residential building (with 85% wholly residential). Of which, 77% were separate housing units, 12% were semi detached or apartment types and 5% are mixed residential-commercial. In Mauritius, traditionally the houses are self-constructed by assigning small contractors to the job, who solely rely on their experience and owners design expectations. For medium and large projects, bigger contractors and construction specialists like architects and engineers are employed. The construction of houses were 92% of concrete walls and roof, 3% concrete walls and iron sheet roofs, and 5% were made out of wood and iron sheets. Although the human settlement patterns in Mauritius is quite dispersed, in terms of basic amenities, almost all (more than 99%) of the houses were connected to nation electricity grid and water systems. 96% of all the housing units had running water in the bathrooms and had modern flush toilets facilities. 8% had their waste collected regularly by municipality or other authorized companies. Almost all the housing units in Mauritius are privately owned, 99% in 2011, among which only 12% were reported to be mortgaged. An astonishing low percentage of 0. 3% of housing units was reported to be public housing in the same year. In terms of the tenure rate of the housing in 2011, 89% of the residents were owner of the hous e they were living in, compared to 8% who were renting or sub-renting. Another 3% were living for free in the housing provided by relatives or employers. It is interesting to note that the average monthly rent in 2000 was Rs 2,300 and increased to Rs 4,400 in 2011, however after adjustment for inflation, the housing rent actually remained the same as 2000. Poverty in Mauritius In 2010, the National Empowerment Fund that was created in 2005 to reduce poverty had enumerated around 70009 households in 225 regions of the country. These represented the families that were most in need of social help. But, the definition of poverty in Mauritius is quite versatile. 8 Bundoo 2006, p175 Exactly 6983 families that lived under national poverty line; According to NEF, Poches de pauvrete, downloaded from http://nef. mu 9 Using the poverty line $1. 25 Purchasing Power Parity (PPP) per person per day, and data from the 2001/02 and 2006/07 Household Budget Surveys, the proportion of poor people in Mauritius is estimated by the Central Statistics Office to be below 1% in both 2001/02 and 2006/07. For developing countries like Mauritius, the $2 a day poverty line is more relevant. Even, using this line, the proportion of poor people is estimated to be less than 1. % in 2001/02 and 2006/07 household income surveys. So, the concept of ‘extreme poverty’ (as internationally defined) is not used in Mauritius. Instead, the concept of ‘relative poverty’ is used. Relative poverty is assessed using data collected at Household Budget Survey (HBS) and a relative poverty line defined on the basis of median household incomes. Household income c omprises income from employment, property, transfer, income from own produced goods and services and imputed rent for non-renting households. Data published by the CSO in the 2001/02 and 2006/07 Household Budget Surveys indicate that the percentage of households having income below the half median increased from 13. 1% in 2001/02 to 14. 3% in 2006/07. Average monthly household income for the poor is estimated at Rs 7,055 against Rs 22,242 for all households. The poverty line was fixed at Rs 3,821, which is the half median monthly income per adult equivalent. So, the official figure for poverty in Mauritius in 2007/07 was 26,400 households, or 7. 9% of the total 335,000 households in Mauritius. This concerned 8. 5% of the national population. From the 2007 Poverty Report, it can be also seen that 55% of the total government expenditure went to ‘Community and Social Services’. Monthly public transfers (social security benefits paid by government) derived by the poorest decile group of households was estimated at Rs 1,367 per household in 2006/07. Public transfers for poorest decile represented 22% of their total household disposable income against 2. 4% for the richest decile. Public transfers were found to be significant on bringing down poverty; it is estimated that if public transfers would have been discontinued, the overall household poverty rate would be 15. % instead of 7. 9%. Characteristics of Low Income Household Understanding the particularities of the poor or low-income households, are very important to know their economic strength and lifestyle. This would help to understand the type and cost of social housing that is offered to them. Again, in 2006/07, the average of ‘low income’ hou seholds in Mauritius was calculated to be around Rs 7,000 (compared to Rs 22,200 for all household), with an average expenditure on Rs 6,500 (compared to Rs 14,300 for all households). 1% of the income came from paid employment, 24% from government support, and the rest from self-employment and odd jobs. In terms of employment, where the national share of employment by sector in 2006/07 was as followed: Primary sector- 9%, Secondary sector- 32% and Tertiary sector- 59%; the structure was a little different for the poor families, as followed: Primary sector- 21%, Secondary sector- 37% and Tertiary sector- 42%. So, it can also be noted that the poorer people were more dominant in agricultural and manufacturing industries, and less present in the service industry. This explains partly, their low income. This phenomenon is also related to their level of education. The study has shown a very clear correlation with the distribution of income and the education level of members aged 20 and above. The higher the incomes, the proportion of the members having passed the primary and secondary education are larger. The share of expenditure on basic items such as food, clothing and housing over total expenditure was 65% for poor households, against 48% for all households. Figure 1 shows the detail expenditure of the poor against all households. It is interesting to note in the report that the average monthly loan repayment10 was Rs 1400 for poor housing, against Rs 4,353 for all indebted households. The highest loan repayment for poor households was on housing11. Figure 1: Expenditure habits of poor households, 2006/0712 As mentioned above, according to the 2010/11 Household survey, 8% who were renting or sub-renting. In 2006/07 the figure was 8. 4% for all households, but for the poor households, 16. 7% were renting their housing. The rest owned their houses or were provided free by relative or employer. The average poor household had a size of 4. 0 members, however the house had on average 3. 7 rooms, compared to average of 3. 7 members with 5. 2 rooms for all households. The amount poor households 10 11 Including, loans or purchase on credits, for housing, furniture, electric appliances, personal loans and other loans. 26% of the poor households had housing loans, which on average was Rs 2,491 12 Source: CSO 2007, Poverty Report 2006/07, p59 with two or less rooms accounted for 19%, against only 5% for all households13. There were more than one person per room in 63% of the households, against only 29% in all households14. This gives an idea of how poor households lived in a denser indoor environment than their other country man. Low Income Housing in Mauritius Strategies & Institutions Since the 1980’s Mauritius was still an economy based on mono crop agriculture. Sugar cane cultivation had been the economic backbone for centuries of colonization, and only in the 80’s the diversification help Mauritius get out of the trap. Saying so, after independence in 1968, all successive governments regularly reiterate their will to gradually dismantle the ‘sugar estates camps’, which were the housing provided by colonial estate owner to workers. It was important to do so, as they remain powerful physical and psychological symbols of the sugar plantations hierarchy of the 19th century. A study in 1990 revealed that there were still 125 such estates in the country, and on the basis of finding long term alternatives for such residences, the government put pressure on the sugar estates, to phase out these camps and develop housing programs for their workers. The options offered were either to resettle the workers on an alternative site, out of the master’s property, or to sell the land and house to the current resident on the estate (UN, 2000). As seen above, the poor are usually less educated and work in agriculture. And since the structuring of the sugar industry 15 in the last decade, more and more of these people are losing their job, and because of age and education level, they cannot find other jobs. So, an early retirement scheme, worked out by all concerned parties and government, and involves giving a lump sum and a plot of residential land to the worker. The land given to the worker, are usually sugar plantations16 that have been converted to residential with basic infrastructure of road, electricity and water supply. This helps in reusing the abandoned agricultural lands and reduced the pressure of cash reward to the estate companies. In 1983, the house ownership in Mauritius was 66%, and then it rose to 76% in 1990, rose again to 87% in 2000, to reach a high 89% in 201117. Although official figures indicate a very high rate of owner-occupiers compared with other countries, these figures hide other quite serious problems of housing which may culminate into a crisis in years to come if some issues are not addressed in time Social housing programs for low income groups which had begun in the 1960s, gave way to a new housing strategy based on cost recovery through the setting up of a public company, The National Housing Development Company Limited (NHDC) in 1991 (UN, 2000). 13 14 Author calculation from CSO 2007, Poverty report 07, table 4. Author calculation from CSO 2007, Poverty report 07, table 4. 7 15 which currently contribute less than 4% of the GDP and less than 8% of employment 16 Since restructuring, large areas of sugar plantation have been abandoned by the sugar estates 17 Various Source, Boodoo 2006 for 1983 & 1990; 2011 Housing Survey for 2000 and 2011 Until 1991 the Central Housing Authority (CHA) was responsible for the task of building and administering of the low income housings estates. Medium rise apartment type buildings were built and let to the low income groups. The system was not successful at different levels. Firstly, most of the units were rented to low income households, instead of been owned. So, rents were sometimes not been paid, and the residents paid little attention to the built environment. This lend to a rapid degradation of the buildings and amenities. Secondly, although targeted for low income earners, the middle income group could somehow buy the apartment units. Thirdly, due to the deplorable design and soft policy, the CHA estates turned into undesirable living places where social problems grew. In 1991, the responsibility of providing low income housing has been passed the newly established National Development Company (NHDC), and the CHA was renamed the Housing Management Unit (MHU), which just left to administer these estates and collect rents. Another important institution was restructured shift to be noted during the same period. Since its creation in 1963, the Mauritius Housing Corporation, was governmental body was responsible to create housing for the middle income class, while the CHA was doing the same for low income class, financed by loans through the Mauritius Agricultural Bank18. In 1989, the Mauritius Housing Corporation (MHC) was incorporated and renamed the Mauritius Housing Company Limited, which then was more like a bank, to cater better to the need of the housing demands. Then the new MHC, no longer deals with the construction and policy of the social housing, it provides soft loans to those below a certain income level, and started the Plan Epargne Logement, PEL (in English, Housing Savings Scheme), that offer exceptional loan rates to anyone, who would deposit money in MHC bank. Nowdays, the MHC has developed into a one-stop shop for all need of housing services. In additional to loans, it deals with the providing of architectural, structural, legal, technical, insurances and project management services, at nominal or free of charges. Prior to 2006, the social housing responsibility lied solely within the hands of the government. But, as the demand was growing and the government could only built around 900 units a years, with a waiting list of 25,000 housing units, the private sector was called to participate through various PPP (publicprivate partnership) projects. The aim was to raise the rate of construction to at least 1500 yearly19. Another interesting fact is that as from 2009, the government established a policy of Corporate Social Responsibility (CSR) that requires profitable private companies to invest at least 2%20 of their profit, into social help, like donation to NGO, or other social and environmental programs, including housing for the poor. The CSR is the concept whereby companies act to balance their own economic growth with the sustainable social and environmental development of their areas of operation. A company performing highly in CSR is one that goes beyond compliance with the legal framework to actively pursue positive impacts on local communities and its environmental footprint. 18 19 Source: Mauritius Housing Company Ltd, website: http://www. mhc. mu/mhc/; retrieved June 2012 Speech of Minister of Lands and Housing, March 2006 20 Source: NEF, http://www. nef. mu/csr/, retrieved June 2012 Low Income Housing Types and Finance Up to date, there are five main players in the housing sector. They are the Commercial Banks, the Insurance Companies, the Mauritius Housing Company Ltd (MHC), the National Housing Development Company LTD (NHDC) and the Housing Division of the Ministry of Land and Housing (Joseph, 2007). The role of the commercial and insurance companies is to offer housing finance facilities, in addition of their usual core activities. However, the other three players have a very important role in the provision of housing to the general public of Mauritius, but to especially the low and lower middle income group. Even if the government continued to build some apartment types housing, single housing or duplex types were more and more practiced. These types of housing created a better environment for social diversity and were more inclusive in term of equality. It should be noted that in Mauritius, these units are not built in large numbers, but in small numbers between 50 to 100 units spread all over the island. This is due to the availability of land for development and the concentration of poverty in the region. The spread of the social housing and its small numbers help social integration and the balance of the local diversity. Currently, these locations are mostly located in the rural area, as part of the National Plan to increase rural population and develop and reduce the burden on the already dense urban regions. Figure 221 shows an example of a type of social housing units that NHDC are building with the help of the Export-Import Bank of China. Site Bois Mangue St Pierre (Circonstance) Dagotiere Highlands Bambous Montagne Blanche Mon Choisy Cottage La Cure Notre Dame Pointe aux Sables (A & B) Pointe aux Sables (C) Units 108 72 52 84 148 100 98 52 120 60 128 70 21 Source: Ministry of Lands and Housing, retrieved June 2012 Rose Belle Camp Levieux Trou aux Biches Mahebourg Total 76 152 76 78 1474 Figure 2: Example of 1474 housing units scattered into 18 sites around the island. The ‘Firinga Type’ is the one most currently built for the lowest income groups. These are semi-detached units of 40m2 each. It provides for bathroom with toilet and a kitchen table with sink. There are better duplexes types that are constructed for lower middle class. Some houses are spread on two stories and have 2-3 bedrooms with balconies. As the types of housing vary from one income group to another, the financing to these group are not the same. As for the Firinga units the interest rate is fixed at 6. 5% per annum, for other types, the finances vary according to the cost of the housing and household income (that is total income of husband and wife). The current loan scheme from the MHC is as below: For household earning up to 7,500 per month: ? ? ? Long term credit repayment period up to 20 years, depending on the age of the applicants; Subsidized rates of interest of 6. % during the first five years, 8. 0% during the next five years, and 10. 0 % during the remaining years of the repayment period; and A non-refundable Government grant equivalent to 20 % of the gross credit amount subject to a maximum of Rs 30 000. For households earning more than Rs7 500 and up to Rs 10 000: ? ? Long term credit repayment period up to 20 years, depending on the age of the of the applicants; and Subsidized rates of interest of 10 % d uring the first five years, 12 % during the next five years, and 14 % during the remaining years of the repayment period. And finally for those earning more than Rs 10 000: ? ? Long term credit repayment period up to 25 years, depending on the age of the of the applicants; and Rates of interest of 13 % during the first five years, and 14 % during the remaining years of the repayment period. To protect those in the most needs, there are strict eligibility criteria to obtain a NHDC unit like they should not be owner of a housing unit or of a plot of residential land, have made regular contributions o a PEL savings account for a period of at least six months; and priority is given to applicant that reside in the region where the house has been constructed. It should be noted that, in order to relief the burden on the government to provide affordable housing, the MHC provide loans at favorable rates to low and lower middle income applicants who want to construct their own house or want to buy a plot of land. A subsidy for the concrete roof construction, which is considered one of the most expensive parts of the construction, and to prevent the houses have iron sheet roofing. Conclusion: We have seen in this paper that the social movement has been present since before the independence and the movement was stronger after the independence, by the pressure of strong trade unions, and the strong democratic system, where the public opinions and demands could not be undermined. In the welfare state of Mauritius, the government has done greatly in terms of policies and investment to provide decent housing not only for the poor, but also for the less poor. In 2011, the housing ownership approached the 90% and the private sector was also made part into the responsibility to provide housing for all Mauritian, in the way the Mauritians like it. The institutional and financial structure in Mauritius is quite mature after evolving for around 50 years now. It is important to note that Mauritius has a large lower middle and middle class population and that housing benefit are also given to them, in terms of favorable loans rates, and subsidies. References: Websites: Mauritius Housing Company Limited, MHC: www. hc. mu Ministry of Lands and Housing, Housing Division: www. gov. mu/portal/site/housing/ National Empowerment Fund, NEF: www. nef. mu National Housing Development Company Limited, NHDC: www. nhdc-online. com Literature: Bundoo S. K. (2006); Financial and Trade Reforms and Impact on Poverty and Income Inequality: The Case of Mauritius; from Pro-Poor Macroeconomics- Potentials and Limitations, Chapter 8; edited by Cornia G. A. CSO (2009) ; Poverty Report 2006/07 CSO (2011); 2011 Housing Census Main Results Deerpalsingh N. 2011); Access to Social Services for Non-Citizen and the Portability of Social Benefits in Mauritius; From Assess to the Social Services for Non-Citizen and the Portability of Social Benefits within the SADC; Chapter 3, edited by Mpedi L. G. & Smit N. Joseph Mathew (2007); Mauritius Housing Company Limited; AUHF AGM Conference, 17th -21st September 2007 in Ghana Ministry of Housing and Land (2006); Speech of Minister A. Dullul; Government Social Housing Projects on a Private Public Partnership Basis; on 1st March 2006 Phaahla L. E. (2000); Development with Social Justice- Social Democracy in Mauritius; Master’s Thesis presented at Stellenbosch University United Nations (2000); Common Country Assessment, Mauritius; Office of the UN Resident Coordinator, Mauritius, May 2000 United Nations Habitat (2004); Human Settlements Country Profile, Mauritius Vandemoortele M. and Bird K. (2010); Progress in economic conditions: Sustained success against the odds in Mauritius; for Overseas Development Institute

Unemployed Essay Example | Topics and Well Written Essays - 500 words

Unemployed - Essay Example Moreover, the individuals must be â€Å"seeking work† using different strategies to secure paid employment or become self-employed. In addition the individuals have to be â€Å"Currently available for work† in that if work was available they would take it or are willing to become self-employed. The â€Å"without work† criterion distinguished between the employed and the unemployed and it literally means being is situation where a person is lacking work or not being employed is a specific period. Therefore, persons without work are those who have not been working during the time of reference. For example, if a person was engaged in any sort of work even if casual, during the reference period, they are considered employed. Therefore, they do not suit the definition of unemployment even if they were seeking other forms of employment. The other criteria â€Å"current available for work† and â€Å"seeking work† are used to distinguish the unemployed persons from the economically inactive. For example, an old person who have retired cannot be considered unemployed since they are not currently available for work and are not seeking employment. Therefore, the unemployed are those within the economically active age and lack work, are available to do work, and are seeking for work (Hussmanns, Mehran and Varma 95-100). Mankiw and Taylor (564) argue that the â€Å"unemployed person is someone who is without a job and who is willing to start work within the next two weeks and either has been looking for work within the last four weeks or was waiting to start a job.† Therefore, a person who has not been making any efforts to get a job cannot be considered unemployed. Moreover, if a person has other commitments at the period of survey, for example pursuing academic goals, he or she cannot be considered unemployed. Those people with work and are seeking for some other form of work cannot also be considered as unemployed (Mankiw and Taylor 562-565). Conclusively, the

Effective Team and Performance Management Assignment - 1

Effective Team and Performance Management - Assignment Example It also discusses the critical factors affecting team performance and changes required for management of team and performance in the organizational context. Table of Contents 1.Executive Summary 2 2.Introduction 4 3.A Brief Idea of Team Dynamics and Team Formation 5 3.1 Phases of Team Formation 6 3.2 Stages of Group Development 8 3.3 Team Structure 10 4.Factors Affecting Team Performance 11 5.Changes to Be Occurred In the Team through Recommendations 12 6.Identification of Relevant Changes in Leadership and Management Styles 13 7.Conclusion 15 8.References 16 2. Introduction A team can be considered as a group of individuals who are involved for performing different functions towards accomplishing a desired objective. They are required for conducting complex tasks that are assigned by higher authorities in an organizational context. The imperative features of team can be noted as having stronger personalities, possessing effective development of specialized skills and commitment towa rds accomplishing varieties of personal objectives (Quick, 1992). In this similar context, the case study also relates to the issue of effective team and management of performance within the organisation. The case study is related to Electron which is regarded as a manufacturing company engaged in producing components particularly for the telecommunications sector. The company was founded in the year 1997 in the northern region of England. The company possess 150 members, amongst which 90 members are engaged in the department of production. Various departments that have been noted to be operated in Electron are production, marketing and sales, engineering finance and human resource. The company consists of both temporary and permanent employees. The objective of the company is to develop the culture of the company, enhance productivity, provide efficient services to the customers and most significantly gain superior competitive position. The case study focuses on team building aspec ts which are required for maintaining the efficiency of work within Electron, so that effective productivity can be carried out among the team members for the attainment of organisational objectives. In this regard, team building therefore can be signified as a necessary skill that every manager of different organisations focuses on. For developing an organized team, positive attitudes and structured approaches of leadership is required by the managers for handling employees effectively and efficiently (Maddux, 1994). The paper intends to discuss on team dynamics and team formation along with the factors affecting team performance. Moreover, the paper also gives a viewed knowledge about stages of group development as well as changes to be required in Electron to maintain organisational efficiency. 3. A Brief Idea of Team Dynamics and Team Formation According to Belbin’s model, team dynamics is generally utilised by multinational organisations that are involved in creating, re searching and developing new products, processes or solutions. It is considered as a growing trend. Team dynamics can be successful with the quality supervision of a particular team leader for the accomplishment of organisational targets persuaded by the employees and management in the organizational context (Dogaru, 2012). The contribution provides by team leader in the system of team dynamics can be identified as forming coordination amid the team members

THE LAW OF TORT Essay Example | Topics and Well Written Essays - 2000 words

THE LAW OF TORT - Essay Example is any act, omission, establishment, business, condition of property, or anything else which: (a) Injures or endangers the health or safety of other; or (b) Annoys or offends the senses; or (c) Shocks, defies or disregards decency or morality; or (d) Obstructs or interferes with the free passage of any public highway or street, or any body of water; or (e) Hinders or impairs the use of property. The nature of nuisance is nuisance per se or at law or nuisance per accidens or in fact. The scope of a nuisance can be public, private or mixed. Nuisance per se (nuisance at law) is an act, occupation, or structure which is a nuisance at all times and under any circumstances, regardless of location or surroundings. Whereas, nuisance per accidens (nuisance in fact) is one that becomes a nuisance by reason of circumstances and surroundings. Public nuisances causes hurt, inconvenience, or injury to the public, generally, or to such part of the public as necessarily comes in contact to it. While a private nuisance is one which violates only private rights and produces damages to but one or a few people. The liability of the creator of the nuisance as a general rule is that he who creates a nuisance is liable for the resulting damages and ordinarily, his liability continues as long as the nuisance continues. It implies therefore that the person whose duty it is to abate a nuisance should answer for the consequences resulting from its continuance. No one is to be held liable for a nuisance which he cannot All persons who join or participate in the creation or maintenance of a nuisance are liable solidarily. The abatement of a nuisance does not preclude the right of any person injured to recover damages for the past existence. Lapse of time cannot legalize any nuisance, whether public or private. The creation and maintenance of a public nuisance is punishable criminally hence, the element of criminality, which characterizes the acts of creating the nuisance, should

Development of Japanese Bond Essay Example | Topics and Well Written Essays - 2500 words

Development of Japanese Bond - Essay Example The world is growing so fast and every body needs to achieve high goals, money and fame in limited time. For being on top, every person does their best - hard work, efforts and sincerity can only lead a person towards the top. Every field requires day to day changes and updating. The investment industry is not as high profile as it used to be following the global economic crisis but some industries are still up on their feet. There are number of features of bonds, some of them are briefly discussed below: nominal amount, issue price, maturity date, coupon, coupon dates, indentures and covenants sinking fund, options. There are different types of bonds available in market, each of which has its own features and requirements. Bond by foreign entities brings new and wide ways of earning money. Japanese bonds are sold by the Japanese government which offers a number of bonds including revenue bond and subsidy bonds. Japanese bonds are much similar to treasury bonds which are widely sold in United States under the provision of government. Japan has faced lots of problem in the market including a numbers of risks. Bonds sold by foreign markets always have a great scope and region for earnings. There are always low credit spreads on Japanese bonds especially BBB related bonds. CAPM is an additional risk factor in market faced by Japanese bond. Under Y-CAPM -risk and -risk can be determined (Bank of Japan, 2000). The estimated Wright of -risk was 2.6 % in Japan and on the other hand, it is compared with 12.5 % in United States. The big difference between lower degrees of relative risk reflects the risk aversion in Japan. The key problem of Japanese bond is always the policies of Japanese government. Rate of bonds in international markets reflects a lot in economy of country. I n case of Japanese bond deficiency it highly affects the economy of Japan and it shows the competitiveness and performance of Japanese firms (Paul, 2001). This change highly reflects the generally priced risk in Japan. Basically in Japanese market two models are applied i.e. conditional model and unconditional model. The major issue is asset pricing in an international context is exchange

The History of Zero Essay Example | Topics and Well Written Essays - 750 words

The History of Zero - Essay Example Charles Seife (2000) had written in his book, â€Å"The Biography of a Dangerous Idea†, that The word zero comes from the Sanskrit word "Sunya". The meaning of "sunya" is void or empty. In Arabic the word zero is called as "Sifr", which also means for empty or void. The present word zero comes after several modifications of word "zephyrum", which was used by the great Italian mathematician Fibonacci, who was credited for introducing Indian (Hindu) decimal system into Europe in 12th century. The history of zero is believed as very old. However, according to some historian, it exists from the time of Babylonians. In 200-300 BC, Babylonians were using a symbol that is considered to evolve as zero, which presently has seen today. Babylonians used different place value system, as compared to these days. Babylonians used base 60 instead of 10 as used today. Babylonians used two wedge (") symbol for the zero. Suppose that a number 2103 is written according to Babylonians two wedge symbols than it will be written as 21"3. Here for the place of zero they had used two wedge symbols. However, in some places this two wedge symbols differs. In some places, they had used three hooks and a single hook for denoting an empty place. A tablet believed to be 700 BC found at Kish, which is an ancient Mesopotamian city located east of Babylon and todays south-central Iraq, used three hooks to represent the empty place (OConnor & Robertson). The zero was also used in the Jain mathematics. The Bakshali manuscript, believed to be written around 200 BC and 200 AD, used the zero and negative numbers. The "lokavibhaaga" believed to be the oldest known Jain text from India; dated 458 AD had used Zero. If ones think of history of zero or write it, than they will not forget the contributions of great Indian Scholars. Indian scholar Pingala at around 200 BC had used zero in his binary numbers. The modern binary system that is used todays is entirely based on Pingalas Binary systems

The Sources of Competitive Advantage of Rolls-Royce PLC and Tesco PLC Essay - 1

The Sources of Competitive Advantage of Rolls-Royce PLC and Tesco PLC in Harvard Style - Essay Example Traditionally, the competitive advantage business organizations can be fully identified by conducting a value chain analysis. However, recognizing the numerous changes in the businesses’ market environment, this paper will also complement value chain analysis with a method introduced by Shawn Cartwright, the value web analysis. It should be noted that this tool brings into consideration the analysis of competitive advantage of dotcoms or firms whose operations are conducted online or whose brick and mortar strategies are complemented by the online presence (Cartwright and Oliver 2000). This report will be organized as follows. The first section will take a look at the operations of Rolls-Royce Plc. A brief organizational profile will be presented together with the company’s identified core competencies. The second section will also evaluate Tesco Plc in the same manner.  This paper will conclude with a comparison and contrast of the previously identified competitive a dvantages. Rolls-Royce is currently the world’s second-largest airline engine manufacturer behind the General Electric Aviation. Aside from aero-engine, the company is also involved in other industries like defense, marine, and energy markets. The business organization traces its origin in 1971 and was founded by Henry Royce and CS Rolls. With its humble beginning, it has now ascended in the global business marketplace with its cutting edge technology and diverse product offerings. The company is not just a provider of high-quality products but also offers unmatched after sales service to its clients.

Robinson fruit shoot market share Essay Example | Topics and Well Written Essays - 1500 words

Robinson fruit shoot market share - Essay Example To understand better preference and market share, it was worthwhile taking the time to study previous reports on the Robinson Fruit Shoot brand that had been compiled earlier by different studies. This helped the researchers go to the field with knowledge of the perception of the brand and an expectation of opinion. This, however, could, however, influence the objectivity due to response anticipation. From the studies done by Mintel, Fruit Juice, Juice Drinks, and Smoothies - UK - November 2012 and Fruit Juice and Juice Drinks - UK - November 2011 placed Robinson Fruit Shoot at number three and number two respectively as a market share player. They proved that the Shoot was popular among the other brands but was not in pole position as to control the market. That, therefore, seemed to suggest that more marketing and sales were required so as to make the brand the market leader. From another survey by Mintel for Cordials and Squashes in October 2012, there was increased demand for sof t and low alcohol drinks in the United Kingdom hence showing that there was an increasing market for the Shoot as more, consumers preferred soft drinks. The third survey used in the secondary research was Fruit Juices, Energy & Juice Drinks Market Report 2013 that showed the preferences of the children aged between 1 to 15 years, the target consumer group. The survey’s findings are important for the marketers of the shoot to execute a marketing plan that carters for the children’s taste and preferences.

Position Statement (outline) Essay Example | Topics and Well Written Essays - 500 words - 1

Position Statement (outline) - Essay Example II. Another reason for decriminalizing marijuana may be the benefits the government will receive. This is through the amount of capital they might save in terms of the war against drugs. Billions of dollars are used in this expensive battle to catch, prosecute and house those who purchase and sell drugs (Gerber 59). When dealing with marijuana, the costs are soaring high, and it is no more harmful than other regulated drugs. III. There is also the issue of the capital lost in terms of tax collection when it comes to drugs. Revenue lost because the government cannot tax illegal drugs is proving costly in modern day. By decriminalizing marijuana, the government may earn tax revenue from legalizing marijuana than fighting it off the market, losing revenue in the process (Gerber 64). I. The implications of legalizing/decriminalizing marijuana are tremendous. Like anything else legalized in the economy, the government is likely to get involved in the stakes of marijuana production, harvest, and sale. This means that; it would be just like any other drug in the economy at the moment; controlled to profit of a few corporations (Morgan 79). The economy should not be controlled by these few corporations, and neither should the production, harvest, and sale of this drug. II. Just like any other drug, legalizing marijuana may lead to the growth of other trades. Other drugs may make their way into the market, which leads to rise in illegal and illegitimate trade. This implies that, the government might use extra capital annually to fight and combat other drugs off the market (Morgan 98). A. Through decriminalizing marijuana, it is highly likely the revenue a state may receive annually will benefit it tremendously. This is through tax collection, and reduction in costs incurred trying to fight the drug (Gerber 64). B. Decriminalizing marijuana also means the growth of employment opportunities. Many people will get employment through the

Why Critical Thinking Is Important Essay Example for Free

Why Critical Thinking Is Important Essay I. Problem Statement: In normal circumstances, the concept of thinking and knowing cooperate together. However, fear of thinking will influence your preciseness in knowing and may lead to negative consequence. Moreover, without critical thinking, learning cannot be fully process though the brain which will lead to misunderstanding. For example, textbooks could only provide solid answers for every question. As long as you continue to follow the formulas of your mathematic textbook without critical thinking, you cannot think further and understand the real meaning behind the equation. Therefore, critical thinking is important in the accumulation of knowledge. II. Body: A. Why critical thinking is important? 1. Critical thinking is important because it veers a person away from certain mistake. 2. According to â€Å"Thinking vs. Knowing: When Facts Get In the Way†, by Victor E. Ferrall, Jr, he remind us that â€Å"Of course, some knowledge is imprecise, e.g., if any of our kid is going to have a problem sleeping it will be Bobby, or Mom always brings her famous fruitcake to a party.† 3. Indeed, often the information that others provide us could be inaccurate. Hence, we should always use our brain to think and understand the other side’s point of view in order to avoid insufficient knowledge. B. Amiss knowledge is dangerous if you don’t think critically. 1. Knowledge can sometimes be used to control or to dominate people. Therefore, we have to be critical about knowledge. 2. For example, In â€Å"Thinking vs. Knowing: When Fact Get in the way†, it give an example that the society use imprecise information to misleading people, it reports that â€Å"when a religious sect â€Å"knows† the word will end on a date certain and it doesn’t, the usual response is, not to think about why the world did not end, but rather to choose a new deadline, i.e. create new â€Å"knowledge.† 3. Even religious will use amiss knowledge to influence people’s belief, as a result, we should be careful with all the knowledge we learn from others because it may be wrong. Furthermore, if we can manage to be critical in thinking, then we can change and correct whatever mistaken knowledge when we receive it and thereby, won’t be manipulate by others. C. Why people avoid to critical think? 1. People avoid to critical thinking because they don’t want to expose from the hidden story that could probably harm their ideal image. 2. In â€Å"The need to know and the fear of Knowing†, written by Abraham H. Maslow, he claims that â€Å"we tend to be afraid of any knowledge that could cause us to despise ourselves or to make us feel inferior, weak, worthless, evil and shameful.† 3. Our weakness leads us away from the freedom of thought. Slowly, you will start losing your freedom by living in a routine that does not require you to think. Meanwhile, when we start to lost our freedom slowly, living in a routine that does not require us to think, we are enslaving to the rule and control by the social structure. D. Why we should critical thinking? 1. We should think critically because it establishes liberty and intelligent. 2. According to the book named Krishnamuti, the writer believes that â€Å"to be free is to be intelligent, but intelligence does not come into being by just wishing to be free; it comes into being only when you begin to understand your whole environment, the social, religious, parental and traditional influences that are continually closing in on you.† 3. Likewise, freedom requires you to think clear, open minded and rational before you apprehend the concealed stories. As soon as you realize the context, you will receive intelligent that could allow you to break down your fear and stand up for your freedom. III. Conclusion: In short, critical thinking is the major process when receiving knowledge. With this process, we can be able to seek the imprecise information and free from the power of regulation.

The Education Games In Primary Schools Education Essay

The Education Games In Primary Schools Education Essay While educational games might be very important to the learning process, one of the biggest downfalls of this genre is that the learning objective is quite evident to the learner and often doesnt have much meaning for the learner. In more interactive educational games, the learning objective is submerged in a rich world that creates learning opportunities [Ahuja, Mitra, Kumar Singh, 1994]. Despite the mixed success of educational games designed specifically for learning, the impact of digital gaming has drawn many educators and researchers to question how they might be used to facilitate student learning. Over the past decade, the use of educational gaming has prompted considerable attention in exploring how and why games might be powerful tools in the classroom. As a result of this interest, there are potential benefits of this for education and learning in schools. Some important reasons why educational games should be fully implemented in primary schools are enhancing learning sk ills, engaging and motivating the children and preparing them for living and working in the 21st century. The first reason why educational games should be implemented in primary schools is to enhance learning while developing Information and Communication Technology (ICT) skills. In playing educational games, it is evident that skills and competences are developed. Using teacher evaluations of mostly simulation and quest-based educational games found numerous skills to be developed through their use [McFarlane, Sparrowhawk Heald, 2002]. Some of the skills developed playing educational games are, strategic thinking, planning, communication, decision-making, personal skills, spatial skills and social skills. Some educational games cultivate these skills by just engaging in them. If educational games have such a great impact on the development of a child, it should be incorporated in the curriculum of our primary schools. It will create a learning-based environment in which the children can fully utilize their learning capabilities. While the curriculum set by the Ministry of Education is academic, educational games will develop the basic motor skills in children of that level. The challenge is to identify how a certain educational games would connect to the curriculum. Educational games are tools to engage children in learning. The game is the hook or the stimulus, both for the learner and, in many cases particularly at primary level, for developing a rich and wide learning context. In classes, educational games provide a particular focus in one subject, for example, Mathematics or English Language but it is still valued as a stimulus for learning. An example of an educational game is Simcity which can be used to teach aquatic habitat in the subject area of Science. Educational games offer a rich mix of audio, video, text and the manipulation of the mouse to enhance learning. There is no comparison with an inert textbook. Educational games facilitate the multiple intelligences of children such as verbal, mathem atical and spatial. The second reason why educational games should be implemented in primary schools is to engage and motivate children via a student-centered approach to learning. Children can enter environments in games that would be impossible to access in any other way, for example going back in history, understanding the complexity of running a major city, managing entire civilizations or nurturing families. Games require engagement with complex decisions by allowing the player to explore the effects of different choices and a multiplicity of variables. Ongoing and responsive feedback on choices is usually given which encourages the users to discover new limits to their abilities. Games stimulate conversation and discussion since players are able to share ideas, hints and tips in what increasingly tends to be a very lively and supportive learning community [ELSPA, 2006]. Educational games allow children to interact and the nature of the games provides three main factors for motivation: fantasy, challenge and curiosity [Malone, 1981]. Fantasy relates to the use of imagination and the childs inherent inclination towards play. It provides a way for the children to feel freedom to fail, experiment, interpret and identify. Challenge is created by the task or puzzle in an educational game and when appropriately aligned with the childs ability level, the challenge falls within their zone of proximal development. Curiosity here is the sense of testing the educational game or exploring to determine what happens if the child does a certain task. Educational game creates a way for children to be motivated at the cognitive level and in using the new technologies; these games will have a greater impact on childrens everyday lives. One excellent example of motivating children via a student-centered approach is the world education games originating from Australia. Students play Literacy, Mathematics and Science against fellow students in a live, global forum. The teachers role is a facilitator of learning. Feedback is provided for participants while they develop their ICT skills. Finally, the third and most important reason why educational games should be implemented in primary schools is to prepare the children for living and working in the 21st century. Technology has certainly taken over many aspects of life. Children of today are using computers more often as well as handheld consoles. Teachers and school leaders want their children to be prepared for the world of work and to see them inspired towards a relevant future career. Educational gaming can help equip children with the skills required to adapt to the outside world. While the Ministry of Education is slowly implementing the game-based learning in schools, teachers are using the computers in their schools to facilitate educational games and provide game-based projects to the students. Educational games will provide the learning outcomes beneficial to excelling in the higher levels of education. With technology advancing at a rapid rate, individuals will be required to have skills in computing and o ther electronic devices in the future. If educational games are implemented in primary schools, it will certainly prepare the children for the future and it will provide a new perspective of learning in schools. In conclusion, it is clear that educational games present an opportunity to engage students in activities, which can enhance their learning. Like any successful outlay, outcomes need to be well planned and classrooms carefully organized to enable all children to engage in learning. Educational games seem like a viable way for the future learner to bring their existing interests, skills and knowledge into the classroom and then use the games as a hook or stimulus to build the activities for learning around them. Educational games provide a forum for learning in a happy way while developing cognitive and psychomotor skills. It prepares the child for their future life and so it is imperative that educational games should be implemented in primary schools in Trinidad and Tobago.

A Guide To New Zealand Vacations

A Guide To New Zealand Vacations New Zealand is a country situated in the southern hemisphere close to Australia. New Zealand is basically made up of two islands. One is the North Island and the other South island. There are many smaller islands that are a part of the country. It enjoys a temperate climate due to which there is a variety of flora and fauna. Europeans barring a minority of Maoris mainly inhabit it. Its favorable climate has made New Zealand a destination of choice to people across the world. It is accessible to Europe and America by air. Many tourists travel here during vacations and various airlines offer competitive rates to travelers. Flights operate from major cities in New Zealand and are well connected with major cities of the world such as London, New York and Tokyo. These flights offer economy class and executive class bookings that suit the budget of various travelers. Some of the airlines offer special packages for vacations. These packages may include a free hotel booking at the destination for a specific period. They may also offer discounts on group bookings. There are some airlines that offer cash back facility if bookings are done through a credit card. Online bookings are usually granted a good discount. Many of the airlines guarantee lowest prices. If travelers find something cheaper, the fare is refunded by some airlines as a policy decision. The flight itinerary can be planned and booking for all the places can be made at the starting station. Another additional feature that includes the fare is travel insurance. Such Insurance schemes may cover cancellations at last moment due to unforeseen events. Accident and baggage loss are some other insurance covers offered by airlines. Long haul flights offer bookings without service fees. The flexibility of return dates and economic costs are major attractions of booking long haul flights for both domestic and international travel. Information about airfares of major airlines is easily available on the Internet. A tourist can make vacations cost effective and affordable by researching this information. New Zealand Vacation Costs New Zealand is often termed as a country of Gods. There is dramatic variation in the terrain of New Zealand. It ranges from geyser to glaciers, from rainforests to meadows. The range in variety in a limited area is the cause for many tourists to opt for New Zealand as tourist destination. Vacations to New Zealand can be planned at costs affordable to the travelerà ¢Ã¢â€š ¬Ã¢â€ž ¢s budget. The cost depends upon the travel destination and mode of transport. The first step of vacation is finding cost effective airfares. The duration of stay at particular destinations calls for hotel bookings. New Zealand offers accommodation at affordable cost. Travelers can opt for package tours that arrange for all travel and hotel bookings. Some of these include meals in their costs. This effectively reduces costs and the effort to find appropriate restaurants. Flexibility pass is offered to package tour travelers. This helps the tourist to break off at a required destination from the main tour and rejoin at a later stage. For the elite traveler there is an option to avail of exclusive services. Cars of choice can be arranged through the travel desk of the resort for sightseeing. This comes with an extra cost. Executive rooms or suites can be obtained with panoramic view of beaches or mountains. Specialized services such as usage of spa or pool are also a part of service for customized travel. Sight seeing tour operators mostly arrange sightseeing tours. Some of the tour operators arrange accommodation in tents. They have trailers that cater to food and luggage locker facilities. These tours are extremely popular for experiencing wilderness. Cycles or mopeds can be rented for traveling to nearby places. These tours include canoeing for free and serenity of lakes can be experienced at no extra costs. Costs of these vacations can be ascertained by logging on to the net. Various websites provide information on travel and tour options. A combination of best service with reasonable costs can be obtained through a little research. Planning Your New Zealand Vacation New Zealand is a land of contrasting terrain and weather in a compact area. This is the feature that helps the traveler to experience varied ecological terrain without having to travel long distances. The diversity in wildlife has helped New Zealand carve a niche in the tourism world market. New Zealand offers a variety of tours and packages to travelers. Tour operators can help in planning a vacation tailor made to suit the requirement of tourists. There are coach tours and independent tours that provide adventure and sight seeing tours. The offers vary from budget hotel accommodation to boutique hotels. Camper vans give a different experience to tourists. Options on the mode of transport used during the tours can decide the cost of the tour. It is recommended that accommodation bookings be made well in advance to avoid last minute disasters. Many tour operators provide information about the rich natural beauty of New Zealand that may help in planning the tour. The options may range from going on adventure tours, wildlife encounter tours to cultural tours. If traveling from a foreign country, the documents required for travel such as passports and visas need to be carried along throughout the travel. It is advisable that tourists, who are under medication, take details of medical care and medical formulas of prescribed medicines before starting on the trip. The kind of clothing to be carried will depend on the weather of the choice of destination. Information about the temperature and weather of a particular place can be obtained from websites of resorts or hotels. Standard itineraries are a safer option for travelers who do not want to take a risk during their vacation. In this way, tourists may find it easier to plan their holiday tours that cater for their budget. Additionally, they would also know exactly what to expect from the trip. A well-planned holiday to New Zealand can be an enjoyable experience. A Guide to New Zealand Vacations Tourists all round the world increasingly favor vacations to New Zealand. This country is known for its ecological diversity and for its varying climatic conditions across the country. Most places have sunny weather throughout the year. It would be beneficial to take suggestions from a professional travel planner if going on vacation to New Zealand, especially from a foreign country. Information can also be sourced online. It is important to know about the place and its history before planning a vacation. There are many websites that provide information about the history, wild life parks and natural beauty of New Zealand. Travelers are also informed about the time zones and exact season to visit these places. It also enlightens travelers about its origin and cultural heritage. Most of the web sites also provide information that may help tourists to plan their program. New Zealand offers a choice of tourist spots and tours. Glaciers with skiing grounds, geysers with hot springs can be visited in a short span of travel time. A choice can be made between a wide variety of tours involving camping, visit to nature parks, adventure tours, wildlife sightseeing or cultural tours. Every country has a set of regulations for foreign travelers. Information about formal documents such as passport and visas are necessary to avoid legal implications. Information about exchange rate of currency will help in planning expenditure. Places that offer currency exchange are also indicated on websites. Medical and emergency facilities that are offered to the tourists can also be known from websites or travel planners. Information about accommodation and their availability is also available with agents. Cost effective airfares and the airlines offering them can be accessed online. Many places in New Zealand have accommodation guides to help first time travelers. Additionally, maps and travel routes can be used while planning a trip to New Zealand.

Lorraine Hansberrys A Raisin In The Sun :: essays research papers

Ronils Review of A Raisin in the Sun. This is probably the first play I've ever seen that I REALLY HEATED. A Raisin in the Sun The Madison Repertory Theatre has produced many plays by African American playwrights recently, such as last year's From the Mississippi Delta, but their most recent, Lorraine Hansberry's A Raisin in the Sun is certainly one of the veryWorst. The play starts in a darkened living room. Ruth Younger wakes her family on a Friday morning. Her father-in-law has recently died, and the family is awaiting the arrival of the insurance money. Her husband, Walter, has plans to use it to buy a liquor store, but wife doesn't believe he belongs in business. Beneatha, Walter's sister daughter, hopes to use the money for her tuition for medical school. Walter's mother, Lena (Mama), plans to use the money for a house for the family. On top of all this, Ruth has discovered that she is pregnant. In an effort to find a true identity, Beneatha has shunned her mother's religious beliefs and has taken an interest in Asagai, a Nigerian student. Asagai brings her a tribal drum recording and a robe from his country. Beneatha is also being pursued by another suitor. George Murchison, a student belonging to the upper class also has an interest in her, and regards her embracement of African culture as childish. After the money arrives, Mama leaves to "take care of some business." When she returns, she announces just what it was that she did do: she has bought the family a house...in Clybourne Park, an all-white neighborhood. Mama then entrusts the rest of the money to Walter, to invest in his sister's education, and to put the rest into a savings account under his name. Walter promises his son Travis a great future, and promptly invests it in his liquor store. While packing, the family is visited by Karl Linder from the Clyborne Park Community Improvement Association, and a white man. Linder explains that the Younger family might not be welcomed in Clybourne Park, and might be better off living in a black neighborhood. "It has nothing to do with racial prejudice," he explains. To make matters worse, Bobo, Walter's friend comes to say that the third member of their team, who had been entrusted with all the money is gone. Period. In desperation, Walter calls Linder to buy the house back, but after a talk with

Racism in the Film Remember the Titans Essay -- Movie Film Football Ra

In the movie "Remember the Titans" there are many lessons that every person should learn in their life. One of the most important lessons is that of racism. In this day and age some people believe that racism is over because there are no longer any slaves, some people believe that there is still racism but that it is ok. I believe that those people would benefit a great deal from seeing this movie. I know that there is still racism, I also know that it is not ok. There is a scene in this movie where the coach takes the team on a long run in the middle of the night. They end up at the break of dawn at a cemetery. The coach tells the young men of the battle that was fought on that ground. He told of the blood shed on those grounds that turned the whole area red. This can help many people that want to make a difference in this world. They had to stand up for their new knowledge to people that they love and trust. The people in this story go through a great transformation from hating each other to being as close as brothers but I do not feel that the end result is the most important part. These boys had very difficult decisions to make. I think that all these young men were raised to be racists to varying degrees. This graveyard moment was a very clear message that could not be misunderstood. They learned tolerance for those of their loved ones that couldn?t or wouldn?t learn as quickly as they did. If we are to ever overcome the misguided beliefs we gain from our parents we need a very good explanation of why we should believe another way. Without this I do not think that the team would have ever come together because they had been raised to hate each other their whole life. The learned the importance of friendship and what i... ...n effort to get along. Their friendship was so secure and they were so pleased that they had learnt to overcome the racial issues and spent the time to get to know each other. They both still acted as if they were better than each other and they weren?t going to attempt to change this, even when they were playing football together. If something went wrong they would blame each other, or disagree, and always end up fighting and usually about different things, like who was better and right. By observing the friendship emerging between Gerry and Julius other people began to realize that having friends of a different race was not wrong. This also made Gerry and Julius?s friendship grow even stronger as they made a huge impact on the community. They started to understand each other and created a bond that was so strong that their appearance didn?t seem to matter anymore. Racism in the Film Remember the Titans Essay -- Movie Film Football Ra In the movie "Remember the Titans" there are many lessons that every person should learn in their life. One of the most important lessons is that of racism. In this day and age some people believe that racism is over because there are no longer any slaves, some people believe that there is still racism but that it is ok. I believe that those people would benefit a great deal from seeing this movie. I know that there is still racism, I also know that it is not ok. There is a scene in this movie where the coach takes the team on a long run in the middle of the night. They end up at the break of dawn at a cemetery. The coach tells the young men of the battle that was fought on that ground. He told of the blood shed on those grounds that turned the whole area red. This can help many people that want to make a difference in this world. They had to stand up for their new knowledge to people that they love and trust. The people in this story go through a great transformation from hating each other to being as close as brothers but I do not feel that the end result is the most important part. These boys had very difficult decisions to make. I think that all these young men were raised to be racists to varying degrees. This graveyard moment was a very clear message that could not be misunderstood. They learned tolerance for those of their loved ones that couldn?t or wouldn?t learn as quickly as they did. If we are to ever overcome the misguided beliefs we gain from our parents we need a very good explanation of why we should believe another way. Without this I do not think that the team would have ever come together because they had been raised to hate each other their whole life. The learned the importance of friendship and what i... ...n effort to get along. Their friendship was so secure and they were so pleased that they had learnt to overcome the racial issues and spent the time to get to know each other. They both still acted as if they were better than each other and they weren?t going to attempt to change this, even when they were playing football together. If something went wrong they would blame each other, or disagree, and always end up fighting and usually about different things, like who was better and right. By observing the friendship emerging between Gerry and Julius other people began to realize that having friends of a different race was not wrong. This also made Gerry and Julius?s friendship grow even stronger as they made a huge impact on the community. They started to understand each other and created a bond that was so strong that their appearance didn?t seem to matter anymore.

Buddhist view on Abortion Essay -- essays research papers

It is quite clear from a variety of sources that abortion has been severely disapproved of in the Buddhist tradition. It is also equally clear that abortion has been tolerated in Buddhist Japan and accommodated under exceptional circumstances by some modern Buddhists in the U.S. The situation is similar to that of Roman Catholicism, where abortion, though disapproved of in the strongest terms by Church authorities, is still practiced by a large number of devoted Catholics and defended by at least a few. As a Buddhist, I would most likely still be for abortion. Buddhism itself speaks with more than one moral voice on this issue against abortion. The core belief in Buddhism is against abortion, but there are commonly people of this religion that don’t agree with that. For the time in which I will be writing this essay, I am one of those people. Most of my fellow Buddhists believe in the point that you should not be able to choose one life over another. For this reason, abortion cannot be rightly practiced. Although there are exceptions, Buddhism is still an antiabortion religion, it’s just somewhat lenient. Unlike Roman Catholicism, abortion isn’t just a flat out â€Å"no† in this religion. â€Å"The abortion issue usually hinges on whether the fetus is indeed a life in the relevant sense.† (Michael Barnhart) In its early stages, a fetus is not considered a human yet to Buddhists. It is alive, but not a human being. Therefore in some cases abortion can be appropriate. â€Å"One cannot say t...

Contextual Study Questions

Who is the Artist? What kind of Artist are they? Where do they live and work? The artist of the image is Andy Warhol, and is most notable for his works in the Pop Art movement; he lived from 1928 to 1987 and spent the majority of his life in New York City. What is the piece of work? The piece of work in question is an illustration of a variety of beauty products in monochrome with multicultural rectangles spread around the page, all atop a black background. When was it made? Does it have a title?The image was made in 1956, and while having no official title, was an illustration for Harpers Bazaar. What do you think might have inspired the artist? What might the piece be about? The most likely source of inspiration for this piece was from fashion in general as the piece was centered around beauty products, furthermore, as the piece was designated for Harpers Bazaar, which is a fashion magazine, which also brings up the possibility that Andy Warhol was simply told to illustrate the pie ce by the company.This also ties into what the image is about as it too can most likely credited to Andy Warhol being commissioned to do an illustration for Harpers Bazaar, of which the piece is centered about. What materials and processes have been used? From the image, it appears to be made from pencil or graphite with a transparent material of sorts over the illustrations before being printed together on one layer as it was designated for a magazine. Can you describe the use of color? The use of color throughout the piece is conservative as it is only used on the multicultural transparent rectangles that are spread throughout the piece.

Sports and Drugs

Consider if steroids were legal, how much more exciting sports would be and t would be fair to everyone. Why: As an athlete and competing in a high level sport, I easily understand athletes and their reasons for doping in sports. At a high level you’re always striving to be the best you can be ad better than your opponents to win. Also, as a candidate for the Provincial and National Team for Canada I have experience in knowing what you need to know and expect while participating in these events.At a camp for team Canada, WADA showed up unexpectedly and took one of the girls’ urine test. So really this is why the topic of doping in sports caught my attention to is because I can relate to it and I’m interested in learning more about it. Why Illegal: it gives you an unnatural advantage against your opponent. Drugs or blood transfusions can provide a 5 or 10 percent advantage (Thomas Murray, Hasting report). Doping up your body and eliminating the concept of fair pla y is different from exceeding to your best abilities natural and being competitive.When participating in sports, it builds character to be determined, honest, and cooperative, but when an athlete pumps illegal performance enhancing drugs into their system it shows true character on what they would do just to win. It has a big effect on the athlete altogether. Doping also effects the psychological aspect of your morals and becoming a criminal by being dishonest and putting illegal substances in your body, it can be mentally damaging. Not only mentally damaging but doping messes up your body, the natural growth and development of it from unnatural drugs is something all athletes should be concerned about.Sacrificing your body to win isn’t a right way to compete. Most likely sport: From Peter Sullvan: The first overall highest percentage(3. 6) of positive illegal drug tests is cycling, in the 2006 tour de France( Including Floyd Landis in first) the top 5 placed athletes were al l guilty of drug use. Along with Lance Armstrong admitting to doping after winning 7 tour de France titles. Floyd Landis describes cycling as â€Å"Professional cycling is organized crime. † Coming in second not too far behind cycling is Weightlifting with a 3% average of positive testing.Seeing how these athletes need to lift mass amounts of weight, its almost predicted that this sport is top 5 for positive doping statistics. Turkey and Russia are common countries who’s athletes are accused of steroids. Thirdly, Boxing is a candidate for doping in sports with a 2. 9% average. A case in 2007 was where an anti- aging agency was distributing steroids to famous boxers such at Even Fields. Boxing requires strength and stamina and some feel the need to enhance their training with steroids to just be stronger than their opponents. Coming after boxing in fourth, is Triathlon.Athletes involved in this race are super humans, in perspective of many people. To run, swim and bike with out stopping is impressive and takes mass amounts of mental and physical strength. Lastly, Baseball makes top 5 sports in doping with a 2. 5% average in positive testing. Even though this sport isn’t in the Olympics, Major League Baseball players have been known for steroid use in the past of 1999 and early 2000’s, as well this past year 20 players got suspended for steroid use. Types: EPO (Erythropoietin): This is a method of an increase of blood oxygen.Erythropoietin is a natural hormone found in the human body. It revitalizes blood cells to have more oxygen, which then increases anaerobic activity. (Kelland, 2012). CERA(Continuous Erythropoiesis Receptor Activator): This is another form of EPO. It increases your blood oxygen level without having to inject yourself as often. Anabolic Steroids: This is a fake replacement of testosterone to help the body utilize protein allowing the athlete to train with more intensity, along with building muscle mass and strength easier. Another aspect is that it acts as an anti- inflammatory to recovery quickly.  (Kelland, 2012)Diuretics: A substance that can mask illegal substances so they wont be detected. Side effects of weight loss. (Kelland, 2012) Blood Doping: Methods of substances to enhance red blood cell mass, to move more oxygen to muscles which increases stamina. 2 types; Autologous is where you use your own blood from being put aside until needed. Homologous is where you take someone else’s blood that’s the same as yours. (Kelland, 2012) Insulin: This enhances glucose in take that helps increase endurance levels by making the storage of muscle glycogen bigger for the athlete.If not used properly it can lead to low blood sugar which leads to unconsciousness and seizures. (Kelland, 2012) Gender? : Which gender is most likely to dope in sports? Well males are a dominant factor for doping. They are much more likely to dope in sports by using steroids. Steroids effect women in a much more negative effect then it does to men. For women, steroids have side effects such as growing hair in unwanted places, clitoral enlargement, and deepening of the voice.T’s easy to tell when a women is taking steroids because of the testosterone over load in their body and manly features. Their physical, behavioural and functional part of the women’s body are out of natural sync as well. Why would women want to take steroids in the first place? other than getting very strong? Women want equality and by taking steroids they can feel equally strong as men in the same playing field. Who’s in charge? the name is WADA (World Agency of Anti Doping). This organization keeps it fair throughout sports.The Olympic committee wanted an agency like this for all countries to follow to specialize on key activities include scientific research, education, development of anti-doping capacities, and monitoring of the World Anti Doping Code and it was quite a success. A cool fact is that WADA’s headquarters is right in Canada, Montreal. Their objective is to have a doping free sporting environment. Consequences: As an Olympic athlete it is important to keep your body clean of illegal substances. Why? Some of the consequences are quite serious.If caught by WADA (The World Agency of Anti Doping) before the Olympics, he/she is suspended for 6 months or longer. (Freedman, 2012) If an athlete has cheated during an event, and won, their medal is taken from them and the results are re-evaluated. Conclusion: In conclusion doping in sports is a serious social issue that shouldn’t be taken lightly. Doping shouldn’t be seen as a way to make an athlete feel better. Not only are they cheating themselves, but they are unfair to their opponents and should take into consideration what mental and physical harm they are really doing to their bodies.WADA is a great service to help deal with keeping sports all around the world fair by testing athletes for performance enhancing substances in their bodies. As an athlete myself I choose to really look into this topic because I’ve dealt with WADA myself. If you are an athlete, beware of what you put into your body. Its important to train to your full potential without being artificially enhanced with chemicals. The natural way is the way to go! Most important thing learned was how harmful steroids can be to your body and mind. Always important to stay true to yourself and not cheat. Be the best you can be

Medical Immunology

MEDICAL IMMUNOLOGY & SEROLOGY Terence L. Eday, RMT, MT(ASCPi), MPH College of Medical Technology / Medical Laboratory Science University of Perpetual Help System DALTA Historical Perspective †¢ 1773, Voltaire reported on an ancient Chinese custom where dried and powdered small pox scabs were inhaled †¢ 1798, Edward Anthony Jenner, Smallpox vaccination †¢ 1862, Ernst Haekel, Recognition of phagocytosis 1877, Paul Erlich, recognition of mast cells Historical Perspective †¢ 1879, Louis Pasteur, Attennuated chicken cholera vaccine development †¢ 1883, Ellie Metchnikoff developed the cellular theory of immunity through phagocytosis; phagocytic theory; cellular theory of vaccination †¢ 1885, Pasteur discovered therapeutic vaccination; first report of live â€Å"attenuated† vaccine for rabies Historical Perspective 1888, Pierre Roux & Alexander Yersin, Bacterial toxins (Yersinia pestis) †¢ 1888, George Nuttall, Bactericidal action of blood †¢ 1 890, Emil von Behring and Kitasata introduced passive immunization into modern medicine; humoral theory of immunity †¢ 1891, Robert Koch demonstrated the cutaneous (delayed-type) hypersensitivity †¢ 1894, Richard Pfeiffer, Bacteriolysis Historical Perspective (1 of 6 ) 1895, Jules Bordet, Complement and antibody activity in bacteriolysis †¢ 1900, Paul Ehrlich, responsible for the antibody formation theory †¢ 1901, Karl Landsteiner, A, B, and O †¢ 1901-8, Carl Jensen & Leo Loeb, Transplantable tumors †¢ 1902, Paul Portier & Charles Richet, Anaphylaxis Historical Perspective (1 of 6 ) †¢ 1903, Nicolas Maurice Arthus, discovered the Arthus reaction of intermediate hypersensitivity †¢ 1903, Almroth Wright and Stewart Douglas observed the humoral component, opsonin †¢ 1906, Clemens von Pirquet, coined the word allergy †¢ 1907, Svante Arrhenius, coined the term immunochemistryHistorical Perspective †¢ 1910, Emil von Dungern, & Ludwik Hirszfeld, Inheritance of ABO blood groups †¢ 1910, Peyton Rous, Viral immunology theory †¢ 1914, Clarence Little, Genetics theory of tumor transplantation †¢ 1915-20, Leonll Strong & Clarence Little, Inbred mouse strains Historical Perspective †¢ 1917, Karl Landsteiner, Haptens †¢ 1921, Carl Prausnitz & Heinz Kustner, Cutaneous reactions †¢ 1924, L. Aschoff, Reticuloendothelial system †¢ 1926, Loyd Felton & GH Bailey, Isolation of pure antibody preparation †¢ 1938, John Marrack, Antigen-antibody binding hypothesis Historical Perspective 1936, Peter Gorer, Identification of the H2 antigen in mice †¢ 1940, Karl Landsteiner & Alexander Weiner, Identification of the Rh Antigens †¢ 1941, Albert Coons, Immunofluorescence technique †¢ 1942, Jules Freund & Katherine McDermott, Adjuvants †¢ 1942, Karl Landsteiner & Merill Chase, Cellular transfer of sensitivity in guinea pigs (anaphylaxis) Historical Perspective †¢ 1944, Peter Medwar, Immunological hypothesis of allograft rejection †¢ 1948, Astrid Fagraeus, Demonstration of antibody production in plasma B cells †¢ 1948, George Snell, Congenic mouse lines †¢ 1949, Macfarlane Burnet & Frank Fenner, Immunological tolerance hypothesisHistorical Perspective †¢ 1950, Richard Gershon and K Kondo, Discovery of supressor T cells †¢ 1952, Ogden and Bruton, discovery of agammaglobulinemia (antibody immunodeficiency) †¢ 1953, Morton Simonsen and WJ Dempster, Graft-versus-host reaction †¢ 1953, James Riley & Geoffrey West, Discovery of histamine in mast cells Historical Perspective †¢ 1953, Rupert Billingham, Leslie Brent, Peter Medwar, & Milan Hasek, Immunological tolerance hypothesis †¢ 1955-1959, Niels Jerne, David Talmage, Macfarlane Burnet, Clonal Selection Theory †¢ 1957, Ernest Witebsky et all. Induction of autoimmunity in animals †¢ 1957, Alik Isaacs & Jean Lindemann, Discovery of interferon (cytokine) Hi storical Perspective †¢ 1958-62, Jean Dausset et al. , Human leukocyte antigens †¢ 1959-62, Rodney Porter et al. , Discovery of antibody structure †¢ 1959, James Gowans, Lympocyte circulation †¢ 1961-62, Jaques Miller et al. , Discovery of thymus involvement in cellular immunity †¢ 1961-62, Noel Warner et al. , Disctinction of cellular and humoral immune response Historical Perspective †¢ 1963, Jacques Oudin et al. Antibody isotypes †¢ 1964-68, Anthony Davis et al. , T and B cell cooperation in immune response †¢ 1965, Thomas Tomasi et al. , Secretory immunoglobulin antibodies †¢ 1967, Kimishige Ishizaka et al. , Identification of IgE as the reaginic antibody Historical Perspective †¢ 1971, Donald Bailey, Recombinant inbred mouse strains †¢ 1972, Gerald M. Edelman & Rodney Porter, Identification of antibody molecule †¢ 1974, Rolf Zinkernagel & Peter Doherty, MHC restriction †¢ 1975, Kohler and Milstein, First monoclona l antibodies used in genetic analysisHistorical Perspective †¢ 1984, Robert Good, Failed treatment of severe combined immunodeficiency (SCID, David the bubble boy) by bone marrow grafting †¢ 1985, Tonegawa, Hood et al. , Identification of immunoglobulin genes †¢ 1985-1987, Leroy Hood et al. , Identification of genes for the T cell receptor †¢ 1986, Monoclonal hepatitis B vaccine Historical Perspective †¢ 1986, Mosmann, Th1 versus Th2 model of T-helper-cell function †¢ 1990, Yamamoto et al. Molecular differences between the genes for blood groups O and A and between those for A and B †¢ 1990, NIH team, Gene therapy for SCID using cultured T cells †¢ 1993, NIH team, Treatment of SCID using genetically altered umbilical cord cells Historical Perspective †¢ 1996-1998, Identification of toll-like receptors †¢ 2001, FOXP3, the gene directing regulatory-T-cell development †¢ 2005, Frazer, Development of human papilloma-virus vaccine Th e IMMUNE SYTEM What is Immunology? †¢ Study of the molecules, cells, organs, and systems responsible for the recognition and disposal of foreign (nonself) material †¢ †¦ ow body components respond and interact †¢ †¦desirable and undesirable consequences of immune interactions †¢ †¦ways in which the immune system can be advantageously manipulated to protect against or treat disease What is Immunity? †¢ Latin word â€Å"immunitas†, freedom from †¢ It refers to all mechanisms used by the body as protection against environmental agents that are foreign to the body. †¢ Can be either natural (innate or inborn) or acquired (adaptive) Function of the Immune System †¢ Recognize â€Å"self† from â€Å"nonself† †¢ Defend the body against nonself Physiologic function is to prevent infection and to eradicate established infections (sterilizing immunity) Key Characteristics of the Immune System †¢ Innate immunit y †¢ Primary response †¢ Secondary response and immunologic memory †¢ Immune response is highly specific †¢ Immune system is tolerant of self-antigens †¢ Immune responses against self-antigens can result in autoimmune diseases †¢ Immune responses against infectious agents do not always lead to elimination of the pathogen (HIV/AIDS) Major Principles of Immunity (immune response): Elimination of many microbial agents through the nonspecific protective mechanisms of the innate immune system. †¢ Cues from the innate immune system inform the cells of the adaptive immune system as to whether it is appropriate to make a response and what type of response to make. Major Principles of Immunity (immune response): †¢ Cells of the adaptive immune system display exquisitely specific recognition of foreign antigens and mobilize potent mechanisms for elimination of microbes bearing such antigens. The immune system displays memory of its previous responses. à ¢â‚¬ ¢ Tolerance of self-antigens. Cells of the Immune System †¢ Lymphocytes – occupy the central stage; determines the specificity of immunity †¢ Dendritic cells (DCs) & Langerhan cells †¢ Monocyte/macrophages †¢ Natural killer (NK) cells †¢ Neutrophils †¢ Mast cells & Basophils †¢ Eosinophils †¢ Epithelial and stromal cells – provides anatomic environment (secretion of critical factors that regulate migration, growth and homeostasis) Lymphoid Tissues and Organs Primary Lymphoid Organs Sites where pre-B and pre-T lymphocytes mature into naive T and B cells in the absence of foreign antigen; †¢ Fetal Liver, Adult bone marrow, and thymus The INNATE IMMUNE SYTEM INNATE IMMUNE SYSTEM †¢ relies on germ line-encoded receptors to detect a limited set of microbial structures that are uniquely associated with microbial infection †¢ not a function of a single defined physiologic system; rather, it is a product of multiple a nd diverse defense mechanisms Modules of the Innate Immune System †¢ Surface epithelium The phagocyte system – critical for the defense against both intracellular and extracellular bacteria as well as fungal pathogens; aided by opsonins †¢ Acute phase response and complement – variety of secreted proteins that function in the circulation and in tissue fluids; secreted by the hepatocytes in response to the inflammatory cytokines IL1 and IL-6 Modules of the Innate Immune System †¢ Natural killer (NK) cells are specialized in the elimination of infected host cells and in aiding defense against viral and other intracellular infections through production of cytokines(IFN-? ; regulated by type I interferons (IFN-? /? ) †¢ Mast cells, eosinophils, and basophils are specialized in defense against multicellular parasites, such as helminthes; regulated by several cytokines, including IL-4, IL-5, IL-9, and IL-13 Strategies of Innate Immune Recognition 1. Recog nition of microbial nonself – referred to as pattern recognition, based on the recognition of molecular structures that are unique to microorganisms and not produced by the host 2.Recognition of missing self – based on the recognition of molecules expressed only on normal, uninfected cells of the host Targets of Innate Immune Recognition †¢ PAMPs (pathogen-associated molecular patterns) – molecular structures produced by microbial pathogens, but not by the host organism †¢ PRRs (pattern recognition receptors) – receptors of the innate immune system and represents targets of the innate immune system Targets of Innate Immune Recognition Examples of PAMPs include: (1) LPS of gram-negative bacteria (2) LTA of gram-positive bacteria (3) Peptidoglycans (4) Lipoproteins of bacteria (cell wall) (5) Lipoarabinomannan of mycobacteria (6) dsRNA produced by virus during the infection cycle (7) ? -glucans and mannans found in fungal cell wall Receptors of th e Innate Immune System †¢ Broad categories of PRRs: (1) PRRs that signal the presence of infection; expressed on the cell surface or intracellularly Categories of gene products: a. proteins and peptides that have direct antimicrobial effector functions (antimicrobial peptides and lysozyme) b. nflammatory cytokines and chemokines (TNF, IL-1, IL-8) c. gene products that control activation of the adaptive immune response (MHC, CD80/CD86, IL-12) Receptors of the Innate Immune System †¢ Broad categories of PRRs: (2) Phagocytic (or endocytic) PRRs; expressed on the surface of macrophages, neutrophils, and dendritic cells(DCs) (3) Secreted PRRs (mannan-binding lectin and peptidoglycan-recognition proteins Function: a. activate complement b. opsonize microbials cells to facilitate their phagocytosis c. ccessory proteins for PAMP recognition by transmembrane receptors (TLR) Receptors of the Innate Immune System †¢ Toll-like Receptors – comprise a family of type 1 transm embrane receptors characterized by leucine rich repeats (LRRs) in the extracellular portion and an intracellular TIR (Toll/IL-1 receptor) domain; grouped into two classes: (1) TLRs 1, 2, 4, 5, and 6 are expressed on the plasma membrane and detect bacterial and fungal cell wall components; (2) TLRs 3, 7, and 9 are expressed in endosomal compartments and recognize viral nucleic acidsToll-like receptor 4 (TLR4) †¢ expressed predominantly in the cells of the immune system, including macrophages, DC, neutrophils, mast cells, and B cells †¢ also expressed on endothelial cells, fibroblasts, surface epithelial cells, and muscle cell †¢ Signal transducing receptor for LPS, heat sensitive protein associated with the cell walls of MTB †¢ Together with CD14 shown to mediate responsiveness to the fusion (F) protein of RSVToll-like receptor 2 (TLR2) †¢ Involved in recognition of LTA and peptidoglycan from gram-positive bacteria, bacterial lipoproteins, mycoplasma lipoprot ein, mycobacterial lipoarabinomannan, a phenol-soluble modulin from S. epidermidis, zymosan of yeast cell walls, and lipoglycosylphosphotidylinositol T. cruzi †¢ Also shown to recognize two kinds of atypical LPS: L. interrogans and Porphyromonas gingivitis Toll-like receptor 3 (TLR3) Receptor for dsRNA †¢ Can mediate responses to poly(IC) †¢ Expressed on DCs, macrophages, and surface epithelial cells, including instestinal epithelium †¢ Also expressed in CD8+ DCs Toll-like receptor 7 (TLR7) †¢ Involved in viral recognition and both detect nucleic acids together with TLR9 †¢ Recognizes viral ssRNA (derived from RNA viruses); TLR9 (unmethylated DNA derived from DNA viruses) †¢ Expressed primarily on plasmacytoid dendritic cells †¢ Activated by small antiviral compunds, e. g. imiquinoid †¢TLR7-mediated recognition takes place inside the late lysosomes Toll-like receptor 9 (TLR9) †¢ Involved in the antiviral host defense; especially on r ecognition of DNA viruses (HSV) †¢ Expressed in type-I INF-producing plasmacytoid DCs Phagocytic Receptors †¢ Scavenger receptors – cell-surface glycoproteins that are defined by their ability to bind to modified LDL †¢ Macrophage Mannose Receptor (MR) – type I transmembrane protein expressed primarily in macrophages; involved in phagocytosis of bacterial (MTB, P. eruginosa, K. pneumonia), fungal (S. cerevisae, C. albicans), and protozoan pathogens (P. carinii) Cells of the Innate Immune System †¢ Macrophages – most central and essential functions and have multiple roles in host defense (e. i. â€Å"housekeeping functions†); in red pulp of the spleen, it phagocytose and remove from circulation senescent RBCs †¢ Neutrophils †¢ Mast Cells – best known effectors of allergic response; protective role is by rapid production of TNF-? nd leukotriene B4 (neutrophil recruitement) Cells of the Innate Immune System †¢ Eosino phils – found primarily in the respiratory, intestinal, and genitourinary tracts; contains cationic effector proteins toxic to parasitic worms; poor phagocytes †¢ Dendritic Cells – immature DCs reside in peripheral tissues and are highly active in macropinocytosis and receptor-mediated endocytosis; expresses PRRs and TLRs; have roles in the initiation of adaptive immune response Cells of the Innate Immune System Suface Epithelium – lines the mucosal surfaces of the intestinal, respiratory, and genitourinary tracts provide an important physical barrier The Effector Mechanisms of the Innate Immune System The Major Categories of Antimicrobial Effector Enzymes that hydrolyze components of microbial cell walls Antimicrobial proteins and petides that disrupt the integrity of microbial cell walls †¢ Lysozyme †¢ Chitinases †¢ Phospholipase A2 †¢ †¢ †¢ †¢ †¢ BPI Defensins Cathelicidins Complement Eosinophil cationic protein Mi crobicidal serine proteasesProteins that sequester iron and zinc Enzymes that generate toxic oxygen and nitrogen derivatives †¢ Seprocidins †¢ Lactoferrin †¢ NRAMP †¢ calprotein †¢ Phagocytic oxidase †¢ Nitric oxide synthase †¢ myeloperoxidase The Effector Mechanisms of the Innate Immune System †¢ Lysozyme – a. k. a. muramidase; degrades the peptidoglycan of some gram(+) bacteria; highly concentrated in secretions such as tears and saliva †¢ Chitinases – enzymes that degrade chitin; secreted by activated macrophages and presumably play a role in antifungal defenseThe Effector Mechanisms of the Innate Immune System †¢ Defensins – cationic peptides with a broad spectrum of antimicrobial activities against gram(+) and gram(-) bacteria, fungi, parasites, and some envelope viruses; kill microorganisms by forming pores in the membranes; divided into ? – and ? defensins †¢ ? -defensins – presynthesize d and stored in granules of neutrophils and Paneth cells of the small intestine †¢ ? -defensins – produced by epithelial cells and not stored in cytoplasmic granulesThe Effector Mechanisms of the Innate Immune System †¢ Cathelicidins – active against gram(+) and gram(-) bacteria and fungi; produced in neutrophils and stored as inactive proproteins in the secondary granules †¢ Serprocedins – comprise a family of cationic serine proteases with antimicrobial activity (neutrophil elastase, proteinase 3, cathepsin G, and azurocidin); exert its antimicrobial activity by either perturbation of microbial membranes or by proteolysisThe Effector Mechanisms of the Innate Immune System †¢ Lactoferrin, NRAMP, and Calprotectin – antimicrobial activities are due to the ability to sequester iron and zinc †¢ Lactoferrin – found in the secondary granules of neutrophils, in epithelial secretions (e. i. breast milk), in the intestinal epitheli um of infants, and in airway fluids; bacteriostatic (iron sequestration) and bacteriocidal (perturbation of microbial membranes) The Effector Mechanisms of the Innate Immune System NRAMP (natural resistance-associated macrophage protein) – integral membrane protein that functions as an ion pump in the phagocytic vacuoles of macrophage and neutrophils †¢ Calprotectin – member of the family of calciumbinding proteins; microbial activity is by chelation and sequestration of zinc ion ACUTE PHASE REACTANTS †¢ Soluble factors which are normal constituents that increase or decrease rapidly as produ †¢ Not a function of a single defined physiologic system; rather, it is a product of multiple and diverse defense mechanisms